Center for Pharmacogenomics and Translational Research

The Center for Pharmacogenomics and Translational Research (CPTR) includes four active research sections:

  • American Lung Association-sponsored Asthma Clinical Research Center
  • Center for Pharmacogenetics
  • Core Clinical Research Program
  • Nemours Asthma Research Program

CPTR is comprised of a team of multidisciplinary researchers with a range of diverse interests including: Pharmacology, Pharmacogenomics, Genetics, Molecular and Cellular Biology research, clinical trials, outcomes research, and nursing research. Our scientists collaborate among the sections to promote the wide-ranging vision of Nemours research to translate basic and clinical science knowledge to the bedside, the clinic, and the community.

The American Lung Association - Asthma Clinical Research Center (ALA-ACRC) is a network of 18 centers nationwide whose primary mission is to conduct large clinical trials (in diverse populations of people with asthma) that will have a direct impact on patient care and asthma treatment. We also seek to contribute to the body of knowledge, advance our understanding of asthma, and train future clinical scientists.

Our ALA-ACRC is a consortium between the Nemours Children’s Clinic and the University of Florida and has been a center in the network since its inception in 1999. During the span of this collaboration, the American Lung Association has provided Nemours with more than $3 million in support of conducting these important trials. The Nemours ALA site has made significant contributions to the success of the network through patient recruitment and scholarly contributions. To learn more about the work and mission of the American Lung Association - Asthma Clinical Research Centers, visit the ALA-ACRC website.

Pharmacogenetics is a relatively new discipline, which seeks to explore associations between variability in response to drugs and differences in a patient’s genes. Much of the current research efforts of Nemours Center for Pharmacogenetics are focused on asthma treatment, as prior studies have shown that current asthma drugs are effective in only about 50% of patients. This inter-patient variability in response to asthma drugs is related to genetic variation. Knowledge of the genes that are responsible for the inadequate drug response will enable us to predict which drugs work best to treat asthma, ultimately creating “personalized therapies.” A personalized medical approach may be the future of medicine and will likely improve treatment for children and reduce medication side effects.

The Core Clinical Research Program supports Nemours scientists in diverse research areas including studies in Anesthesiology, Endocrinology, and Hematology and Oncology. CPTR research coordinators and staff are available for scientific consultation and support to Nemours clinical scientists interested in conducting research. For consultations, call 904-697-3925.

The Nemours Asthma Research Program involves research into the diagnosis and treatment of asthma in non-ACRC research projects. The targeted research areas of our program include Comparative Effectiveness and Outcomes Research, Sickle Cell Disease-Related Asthma and Lung Disease, Obesity-Related Asthma and Lung Disease, and the Impact of Nutrition on Asthma. Nemours scientists currently have six externally-funded and multiyear grants (including NIH/NHLBI, Thrasher Research Fund, James and Esther King Biomedical Research Program) to study these important areas in asthma care.