Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

TitleHeparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications
Publication TypeJournal Article
Year of Publication2014
AuthorsLiang, Y., & Kiick K. L.
JournalActa biomaterialia
Volume10
Issue4
Pagination1588-600
Date Published2014 Apr
ISSN1878-7568
KeywordsAnimals; Biocompatible Materials; Drug delivery; Drug Delivery Systems; Heparin; Humans; Hydrogels; Nanoparticles; Polymers; Tissue Engineering
Abstract

Heparin plays an important role in many biological processes via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties, such as anticoagulant activity, growth factor binding, and antiangiogenic and apoptotic effects, making them great candidates for emerging applications. Accordingly, this review summarizes recent efforts in the preparation of heparin-based hydrogels and formation of nanoparticles, as well as the characterization of their properties and applications. The challenges and future perspectives for heparin-based materials are also discussed. Prospects are promising for heparin-containing polymeric biomaterials in diverse applications ranging from cell carriers for promoting cell differentiation to nanoparticle therapeutics for cancer treatment.

DOI10.2164/jandrol.107.003970
Alternate JournalActa Biomater
Refereed DesignationRefereed