Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis

TitleEvolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis
Publication TypeJournal Article
Year of Publication2014
AuthorsSherr, J., Tsalikian E., Fox L., Buckingham B., Weinzimer S., Tamborlane W. V., White N. H., Arbelaez A. M., Kollman C., Ruedy K. J., Cheng P., & Beck R. W.
Corporate AuthorsDiabetes Research in Children Network
JournalDiabetes Care
Volume37
Issue6
Pagination1741-4
Date Published2014 Jun
ISSN1935-5548
KeywordsAdolescent; Biomarkers; Blood Glucose; Case-Control Studies; Child; Diabetes Mellitus, Type 1; Female; Glucagon; Humans; Hypoglycemia; Male; Meals; Postprandial Period
Abstract

OBJECTIVE: To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D).
RESEARCH DESIGN AND METHODS: MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2). Twenty nondiabetic (ND) control children were also studied.
RESULTS: In T1D children, MMTT-stimulated increases in glucagon were significantly greater than that in ND children (median increments: year 1, 21 pg/mL [16-30]; year 2, 25 pg/mL [16-30]; ND, 9 pg/mL [5-16]; P = 0.001 and P < 0.001, respectively).
CONCLUSIONS: In comparison with ND control children, exaggerated plasma glucagon responses to mixed-meal feedings are observed in youth with T1D within the first 2 years of diagnosis. Further studies to determine whether suppression of these abnormal responses may help to improve glycemic control are warranted.




DOI10.2337/dc13-2612
Alternate JournalDiabetes Care
Refereed DesignationRefereed