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The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring

TitleThe interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring
Publication TypeJournal Article
Year of Publication2011
AuthorsBeck, R., Steffes M., Xing D., Ruedy K., Mauras N., Wilson D. M., & Kollman C.
Corporate AuthorsDiabetes Research in Children Network(DirecNet) Study Group
JournalPediatric diabetes
Volume12
Issue8
Pagination690-5
Date Published2011 Dec
ISSN1399-5448
KeywordsAdolescent; Blood Glucose; Blood Glucose Self-Monitoring; Child; Child, Preschool; Deoxyglucose; Diabetes Mellitus, Type 1; Female; Fructosamine; Hemoglobin A, Glycosylated; Humans; Male; Serum Albumin
Abstract

OBJECTIVES: To describe the interrelationships of glycemic control measures: hemoglobin A1c (HbA1c), glycated albumin, fructosamine, 1,5-anhydroglucitrol (1,5-AG), and continuous glucose monitoring (CGM) in children and adolescents with type 1 diabetes.
METHODS: In total, 26 subjects of age 4-17 had HbA1c measurement followed within 14 d by three laboratory measures of glycemia and the collection of CGM glucose data (N = 21).
RESULTS: Glycated albumin and fructosamine levels had a higher correlation with each other than with HbA1c. The correlation of 1,5-AG with HbA1c was lower (absolute r value = 0.25). All four measures had a similar degree of correlation with CGM-measured mean glucose (absolute r value = 0.50-0.56) and with hyperglycemic area under the curve (AUC) at 180 mg/dL (0.50-0.60).
CONCLUSION: Each of the four measures (i.e., HbA1c, glycated albumin, fructosamine, and 1,5-AG) had a similar correlation with mean glucose and hyperglycemic AUC-180. 1,5-AG did not correlate with hyperglycemic AUC-180 better than did HbA1c.
DOI10.1111/j.1399-5448.2011.00764.x
Alternate JournalPediatr Diabetes
Refereed DesignationRefereed