Effects of glutamine on glycemic control during and after exercise in adolescents with type 1 diabetes: a pilot study

TitleEffects of glutamine on glycemic control during and after exercise in adolescents with type 1 diabetes: a pilot study
Publication TypeJournal Article
Year of Publication2010
AuthorsMauras, N., Xing D., Fox L. A., Englert K., & Darmaun D.
JournalDiabetes Care
Volume33
Issue9
Pagination1951-3
Date Published2010 Sep
ISSN1935-5548
KeywordsAdolescent; Blood Glucose; Diabetes Mellitus, Type 1; Exercise; Female; Glutamine; Humans; Male; Time Factors
Abstract

OBJECTIVE: To investigate if oral glutamine ameliorates exercise and postexercise nighttime hypoglycemia in type 1 diabetic adolescents.
RESEARCH DESIGN AND METHODS: Ten adolescents (15.2 +/- 1.4 years [SD], A1C 6.9 +/- 0.9%) on insulin pumps were studied. The subjects were randomized to receive a glutamine or placebo drink pre-exercise and at bedtime (0.25 g/kg/dose). A 3:00 p.m. exercise session consisted of four 15-min treadmill/5-min rest cycles. Pre-exercise blood glucose was 140-150 mg/dl and was monitored throughout the night. Studies were randomized crossover over 3 weeks.
RESULTS: Blood glucose levels dropped comparably (52%) during exercise on both days. However, the overnight number of hypoglycemic events was higher on glutamine than placebo (CONCLUSIONS: Glutamine increased the cumulative probability of postexercise overnight hypoglycemia compared with placebo in adolescents with type 1 diabetes. Whether glutamine may enhance insulin sensitivity postexercise requires further study in type 1 diabetes.



DOI10.2337/dc10-0275
Alternate JournalDiabetes Care
Refereed DesignationRefereed