Persistence of individual variations in glycated hemoglobin: analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial.

TitlePersistence of individual variations in glycated hemoglobin: analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial.
Publication TypeJournal Article
Year of Publication2011
AuthorsWilson, D. M., Xing D., Cheng J., Beck R. W., Hirsch I., Kollman C., Laffel L., Lawrence J. M., Mauras N., Ruedy K. J., Tsalikian E., & Wolpert H.
Corporate AuthorsJuvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
JournalDiabetes care
Volume34
Issue6
Pagination1315-7
Date Published2011 Jun
ISSN1935-5548
KeywordsAdolescent; Adult; Aged; Blood Glucose; Blood Glucose Self-Monitoring; Child; Diabetes Mellitus, Type 1; Female; Hemoglobin A, Glycosylated; Humans; Insulin; Insulin Infusion Systems; Male; Middle Aged; Monitoring, Ambulatory
Abstract

OBJECTIVE: To determine the individual persistence of the relationship between mean sensor glucose (MG) concentrations and hemoglobin A(1c) (A1C) from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring (CGM) Randomized Trial.
RESEARCH DESIGN AND METHODS: MG was calculated using CGM data for 3 months before A1C measurements at 3, 6, 9, and 12 months for the CGM group and at 9 and 12 months for the control group. An MG-to-A1C ratio was included in analysis for subjects who averaged ≥4 days/week of CGM use.
RESULTS: Spearman correlations of the MG-to-A1C ratio between consecutive visits 3 months apart ranged from 0.70 to 0.79. The correlations for children and youth were slightly smaller than those for adults. No meaningful differences were observed by device type or change in A1C.
CONCLUSIONS: Individual variations in the rate of hemoglobin glycation are persistent and contribute to the inaccuracy in estimating MGs calculated from A1C levels.




DOI10.2337/dc10-1661
Alternate JournalDiabetes Care